Ondansetron Hcl 2 MG (VOMIF )

You should not use ondansetron if you are using apomorphine(Apokyn) or you are allergic to ondansetron or similar medicines which are granisetron, palonosetron, dolasetron.

To ensure ondansetron is fully safe for you, tell your doctor if you ever had:-

Liver disease

Congestive heart failure, slow heartbeats

‘An electrolyte imbalance such as low levels of potassium or magnesium in your blood

A blockage in your digestive tract may be stomach or intestines

Ondansetron is not approved for use by anyone younger than 4 years old.

Ondansetron orally disintegrating tablets may contain phenylalanine so tell your doctor if you have phenylketonuria(PKU).

Get emergency medical help if you see any signs of an allergic reaction to ondansetron: hives, fever, rash, difficult breathing, swelling of your face, lips, throat, or tongue.

Talk to your doctor immediately if you have:

Headache with chest pain and serve dizziness, fast or pounding heartbeats, fainting

Serve constipation, bloating, or stomach pain

Jaundice(yellowing of skin or eyes)

High levels of serotonin in the body such as agitation hallucinations, fast heart rate, fever, overactive reflexes, vomiting, nausea, diarrhea, loss of coordination, fainting.

Blurred vision or temporary vision loss(lasting from only a few minutes to/ several hours)

Headache

Diarrhea or constipation

Drowsiness

Tired feeling

The usual Adult dose of Ondansetron for vomiting/nausea - Chemotherapy included:

Oral: Highly Emetogenic Cancer Chemotherapy(HEC): Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC also including cisplatin doses of 50mg/m2 or greater.

Moderately Emetogenic Cancer Chemotherapy(MEC): Recommended dose: 8 mg orally twice daily, with the first dose, administrated 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later, then 8 mg orally 2 times a day means every 12 hours for 1 to 2 days after the completion of chemotherapy.

Parental: Recommended dose: 0.15 mg/kg IV, with the first dose(infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses are given 4 and 8 hours after the first dose. Maximum dose: 16mg per dose

The usual Adult dose of Ondansetron for vomiting/nausea - Postoperative

Oral: Recommended dose: 16 mg orally 1 hour before the induction of anesthesia

Parental: Recommended dose: 4 mg IV(undiluted) immediately before induction of anesthesia or postoperatively(vomiting or nausea within 2 hours after surgery)

Alternative route: 4 mg IM(undiluted)

Usual Adult Dose for Vomiting/Nausea - Radiation Included:

Recommended dose: 8 mg orally 3 times daily- Total Body Irradiation: 8 mg orally 1 to 2 hours before each fraction of radiotherapy administered every day.

Single high-dose Fraction Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after the successful completion of radiotherapy

Daily Fractionated Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, along with subsequent doses every 8 hours after the first dose for every day radiotherapy is given

Usual Pediatric Dose for Vomiting/Nausea- Postoperative:

Parental: 1 month to 12 years: less than 40 kg:

Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior following anesthesia induction or postoperatively(vomiting/nausea occurring shortly after surgery)

40 kg and greater:

Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior following anesthesia induction or postoperatively(vomiting or nausea occurring shortly after surgery)

Usual Pediatric Dose for Vomiting/Nausea - Chemotherapy Included:

Oral: 4 to 11 years: Recommended dose: 4 mg orally 3 times daily, along with the first dose administrated 30 minutes before the start of chemotherapy, and subsequently doses 4 and 8 hours after the first dose, then 4 mg orally 3 times daily includes every 8 hours for 1 to 2 days after the successful completion of chemotherapy.

12 years and older: Recommended dose: 8 mg orally twice daily, with the first dose, administrated 30 minutes before the start of chemotherapy, and subsequently dose 8 hours later, then 8 mg orally 2 times daily includes every 12 hours for 1 to 2 days after the successful completion of chemotherapy.

Parental: 6 months to 18 years: Recommended dose: 0.15 mg/kg IV, along with the first dose(infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose. Maximum dose: 16 mg per dose.