Pharma Drugs & Chemicals | Ondansetron Hcl-VOMIFRESH-O, Best Derma Medicine For Pharma PCD Franchise On Monopoly Basis Direct From Manufacturer.
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Ondansetron blocks the actions of chemicals in the body which causes vomiting and nausea. This medicine is used to prevent nausea and vomiting that may be caused by cancer chemotherapy, surgery, or radiation treatment.
You should not use ondansetron if you are using apomorphine(Apokyn) or you are allergic to ondansetron or similar medicines which are granisetron, palonosetron, dolasetron.
To ensure ondansetron is fully safe for you, tell your doctor if you ever had:-
Congestive heart failure, slow heartbeats
‘An electrolyte imbalance such as low levels of potassium or magnesium in your blood
A blockage in your digestive tract may be stomach or intestines
Ondansetron is not approved for use by anyone younger than 4 years old.
Ondansetron orally disintegrating tablets may contain phenylalanine so tell your doctor if you have phenylketonuria(PKU).
Get emergency medical help if you see any signs of an allergic reaction to ondansetron: hives, fever, rash, difficult breathing, swelling of your face, lips, throat, or tongue.
Talk to your doctor immediately if you have:
Headache with chest pain and serve dizziness, fast or pounding heartbeats, fainting
Serve constipation, bloating, or stomach pain
Jaundice(yellowing of skin or eyes)
High levels of serotonin in the body such as agitation hallucinations, fast heart rate, fever, overactive reflexes, vomiting, nausea, diarrhea, loss of coordination, fainting.
Blurred vision or temporary vision loss(lasting from only a few minutes to/ several hours)
Diarrhea or constipation
The usual Adult dose of Ondansetron for vomiting/nausea - Chemotherapy included:
Oral: Highly Emetogenic Cancer Chemotherapy(HEC): Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC also including cisplatin doses of 50mg/m2 or greater.
Moderately Emetogenic Cancer Chemotherapy(MEC): Recommended dose: 8 mg orally twice daily, with the first dose, administrated 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later, then 8 mg orally 2 times a day means every 12 hours for 1 to 2 days after the completion of chemotherapy.
Parental: Recommended dose: 0.15 mg/kg IV, with the first dose(infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses are given 4 and 8 hours after the first dose. Maximum dose: 16mg per dose
The usual Adult dose of Ondansetron for vomiting/nausea - Postoperative
Oral: Recommended dose: 16 mg orally 1 hour before the induction of anesthesia
Parental: Recommended dose: 4 mg IV(undiluted) immediately before induction of anesthesia or postoperatively(vomiting or nausea within 2 hours after surgery)
Alternative route: 4 mg IM(undiluted)
Usual Adult Dose for Vomiting/Nausea - Radiation Included:
Recommended dose: 8 mg orally 3 times daily- Total Body Irradiation: 8 mg orally 1 to 2 hours before each fraction of radiotherapy administered every day.
Single high-dose Fraction Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after the successful completion of radiotherapy
Daily Fractionated Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, along with subsequent doses every 8 hours after the first dose for every day radiotherapy is given
Usual Pediatric Dose for Vomiting/Nausea- Postoperative:
Parental: 1 month to 12 years: less than 40 kg:
Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior following anesthesia induction or postoperatively(vomiting/nausea occurring shortly after surgery)
40 kg and greater:
Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior following anesthesia induction or postoperatively(vomiting or nausea occurring shortly after surgery)
Usual Pediatric Dose for Vomiting/Nausea - Chemotherapy Included:
Oral: 4 to 11 years: Recommended dose: 4 mg orally 3 times daily, along with the first dose administrated 30 minutes before the start of chemotherapy, and subsequently doses 4 and 8 hours after the first dose, then 4 mg orally 3 times daily includes every 8 hours for 1 to 2 days after the successful completion of chemotherapy.
12 years and older: Recommended dose: 8 mg orally twice daily, with the first dose, administrated 30 minutes before the start of chemotherapy, and subsequently dose 8 hours later, then 8 mg orally 2 times daily includes every 12 hours for 1 to 2 days after the successful completion of chemotherapy.
Parental: 6 months to 18 years: Recommended dose: 0.15 mg/kg IV, along with the first dose(infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose. Maximum dose: 16 mg per dose.
Ondansetron can cause serious heart problems, especially if you use some medicines at the same time, including antidepressants, antipsychotics, heart rhythm medicines, and medicines to treat cancer, HIV, malaria, or AIDS. Tell your doctor about the medicines you start or stop using during your treatment with ondansetron.
Taking ondansetron while the intake of other medicines can cause high levels of serotonin to build up in your body, a condition called “serotonin syndrome”, which can be fatal. Tell your doctor if you use medicines which are:
Medicine to treat depression
A narcotic(opioid) medication
Medicine to treat a psychiatric disorder
Medicine to prevent nausea and vomiting
Ondansetron may weaken your thinking or reactions. Be careful if you drive or do activities that require you to be alert.
There is no specific study in humans looking at the use of ondansetron during breastfeeding. If ondansetron medicine is necessary to use, it is not usually a reason to stop breastfeeding. A different drug might be considered, especially while breastfeeding a newborn or preterm infant. Talk to your doctor about all your breastfeeding queries.
There are no studies that found a higher chance of pregnancy loss, preterm delivery(delivery before 37 weeks of pregnancy), or low birth weight when ondansetron was taken during pregnancy.
At the higher doses, there are several reports showing that ondansetron use might cause a heart rhythm problem(called QT interval prolongation) in the person taking an abnormal heart rhythm known as Torsades de Pointes. If you are taking this medicine you can ask your doctor about how to notice changes in your heart rhythm
Ondansetron is used to prevent vomiting and nausea which are caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications known as serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, which is a natural substance that may cause vomiting and nausea.
Take the missed dose as earlier as you remember it. Nevertheless if it almost the time of the next dose, skip the missed dose and continue with your regular medication schedule. Please do not take a double dose to make up for a missed dose.
Always keep this medicine in a tight container, and out of the reach of children. Store the tablets and rapidly disintegrating tablets away from light, at room temperature or in refrigerator, excess heat, and moisture(not in a bathroom).
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